Synthesis and Characterization of Novel Compounds Containing of Imidazolidinone and Oxazepine Rings

The compound 3-[4̄-(4^=-methoxy benzoyloxy) benzylideneamino]-2-thioxo-imidazolidine-4-one [III] was prepared from the cyclization of thiosemicarbazone [II] with ethyl α -chloroacetate in the presence of fused sodium acetate. Treatment the later compound with acetic anhydride yielded the corresponding 1-Acetyl-3-[ 4̄- (4^=- methoxy benzoyloxy) benzylideneamino] – 2 – thioxo - imidazolidine-4-one [IV]. 1,3-Oxazepine derivatives [V]a-d and [VI]a-d are obtained from the reaction of compounds[III] and [IV] with different acid anhydrides, in dry benzene. The FTIR and ^1HNMR spectroscopy are indicated a good evidence for the formation of the synthesized compounds. Some of the synthesized compounds have been screened against E.coli , Staph. aureus , Psenudomonsaeruginosa and Bascillus cereus . They exhibited moderate to weak antibacterial activity unless compound [V]d did not show any biological activity.