Title of article :
Spectrophotometric Determination of Mefenamic Acid in Pharmaceutical Preparations
Author/Authors :
dikran, sarmad b . university of baghdad - college of education for pure science (ibn al-haitham) - department of chemistry, Iraq , al-joboury, moen i. university of baghdad - college of education for pure science (ibn al-haitham) - department of chemistry, Iraq , mohammed, alaa k. university of baghdad - college of education for pure science (ibn al- haitham) - department of chemistry, Iraq , naser, ahmed s. university of tikrit - college of science - department of chemistry, Iraq
Abstract :
A simple, accurate and precise spectrophotometric method has been proposed for the
determination of Mefenamic acid(MA) in dosage forms. Proposed method based on the
reaction of cited drug with 1,2-Naphthoquinone-4-Sulfonic sodium (NQS). The optimum
experimental condition have been studied. Beer's Law is obeyed in the concentration range
0.5-10.0 µg/mL at 450nm with detection limit of 0.189µg/mL. Effect of pH, reaction time,
and volume of NQS on the determination of Mefenamic acid, have been examined. The
proposed method has been successfully applied for the determination of Mefenamic acid in
pharmaceutical preparations.
Keywords :
1,2-Nphatha quinona-4-Sulfonic sodium , Mefenamic acid , Spectrophotometric
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
