Synthesis ,Characterization and Study Biological Activity of Some New 1, 3, 4-Thiadiazole and Pyrazolone Derivatives Containing Indole Ring

This work involves synthesis and characterization of some new 1, 3, 4-thiadiazole or pyrazoline derivatives heterocyclic containing indole ring. The new 2-amino-1, 3, 4-thiadiazole derivatives[IV] and [V]a, b were synthesized by cyclization reaction of 2-methyl-1H-indole-carbothiosemicarbazide[III] in H2SO4 acid or by reaction of indole-3-acetic acid or indole-3-butanoic acid with thiosemicarbazide in the presence of phosphorous oxychloride, respectively. Amide derivatives [VI]-[VIII] were synthesized by the reaction equimolar of 2-amino-1, 3, 4-thiadiazoles and (acetyl chloride, benzoyl chloride, anisoyl chloride and heptanoyl chloride) in DMF and pyridine as accepter. The newpyrazolonederivatives [XI]a, bwere synthesized from heating under reflux equimolar from a mixture of acid hydrazides [X]aor [X]b and ethylacetoacetate in absolute ethanol. Acetyl pyrazolonecompounds[XII]a, bwere synthesized by the reaction of pyrazolonederivatives [X]a or [X]b with acetyl chloride in 1,4-Dioxane in present of calcium hydroxide to give 4-acetyl pyrazolone derivatives[XI]a, b. The new aryl hydrazone derivatives of pyrazoline [XIII] and [XIV]were synthesized by the reaction of one mole of compounds [XII]a or [XII]b with one mole of phenyl hydrazine or substituted phenyl hydrazine in ethanol.All the synthesized compounds have been characterized by melting points , FTIR, 1HNMR and Mass spectroscopy (of some of theme).