Title of article :
Synthesis, Characterization and Antibacterial Activity of New Chalcones Derived from New Aldehyde; 4-[5-(4`-tolyl)-1,3,4-thiadiazole-2-yl] benzaldehyde
Author/Authors :
tomma, jumbad h. university of baghdad - college of education for pure science (ibn al- haitham) - department of chemistry, baghdad, Iraq , khazaal, mustafa s. central organisation of standardisation and quality control - standrads department, iraq , baker, rajaa k. university of baghdad - colloge of education for pure science (ibn al-haitham) - department of chemistry, Baghdad, iraq
Abstract :
New chalcones of 3-{-4-5-4 -tolyl)-1,3,4-thiadiazole-2-y1) phenyl}-2-propene-1-one-3- or 4- substituted phenyl have been prepared from condensation of a new of 4-[5-(4`-tolyl)-1,3,4 thiadiazole-2-yl] benzaldehyde (which is synthesized by the reaction of 2- amino-5- (4`-tolyl) -1,3,4-thiadiazole and benzaldehyde) with 3- or 4- substituted acetophenones in alkaline medium. The physical, CHNS analysis and spectral data of the synthesized compounds were determined. The biological activity evaluated of new compounds showed that many of these compounds possess antibacterial activity.
Keywords :
1,3,4 , thiadiazole , chalcones , aldehyde , antibacterial activity
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
