Effect of Carthamus Tinctorius Safflower Aqueous Extract Against Nickel Chloride Induces Hematotoxicity and Immunotoxicity in Adult Male Rabbits

This study was designed to show, the role of Carthamus tinctorius safflower aqueousextract against toxicity of nickel chloride (NiCl2). Twenty male, rabbits were used and dividedinto four groups (with 5 rabbits in each group); group (control group) received normal diet,group II received orally 100mg/kg NiCl2 for six weeks, group III received 100mg/kg NiCl2and 100mg/kg extract six weeks, group IV received 100mg/kg NiCl2 and 200mg/ kg extractsix weeks. Hematological parameters showed (RBC (Red blood cells), Hb (Hemoglobin),PCV (Packed cells volume) decreased and WBC (White blood cells) increased) significantchanges (P 0.05) compared with control group. Immunological parameters (IgG, IgA andIgM increased) and oxidative stress factors (MDA increased and GSH decreased) showsignificant changes (P 0.05) compared with control group. While, safflower aqueousadverse the negative effects of NiCl2 and causing ameliorative effects on all hematologicalparameters, hematological immunological parameters and oxidative stress factors showed nosignificant changes (P 0.05) compared with control group. It was concluded that flowerextract of Carthamus tinctorius has been antioxidant role against nickel chloride toxicity inrabbits.