Author/Authors :
Cristina Rotar, Ioana Clinic of Obstetrics and Gynecology - University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5,400006 Cluj-Napoca, Romania , Elena Dumitras, Diana Department of Economic Sciences - University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca - Calea Manastur 3-5,400372 Cluj-Napoca, Romania , Anghel Popp, Radu Department of Molecular Sciences - University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5,400006 Cluj-Napoca, Romania , Maria Petrisor, Felicia Department of Molecular Sciences - University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5,400006 Cluj-Napoca, Romania , Cotutiu, Paul Clinic of Obstetrics and Gynecology - Emergency County Hospital, Cluj-Napoca, Romania , Stamatian, Florin Clinic of Obstetrics and Gynecology - University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5,400006 Cluj-Napoca, Romania , Muresan, Daniel Clinic of Obstetrics and Gynecology - University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5,400006 Cluj-Napoca, Romania
Abstract :
Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia.Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN)and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy wasperformed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotypingwas determined. For statistical analysis purposes or and chi-square were used at a level of significance of<0.05.Results. No linkhas been found in the detection of CT genotype in cases versus controls, or = 0.8295, [0.42, 1.62]. An inverse correlation has beenfound between T allele and HSIL, or = 0.2121, [0.0473, 0.9517],𝑝=0.0866.Conclusion. No link has been found between VEGF+936 C/T and cervical intraepithelial neoplasia.
