Author/Authors :
Kreienbring, Katrin Department of Gynecology - Campus Virchow Klinikum - Charit ́eUniversit ̈atsmedizin Berlin, Berlin, Germany , Franz, Annika Department of Gynecology - Campus Virchow Klinikum - Charit ́eUniversit ̈atsmedizin Berlin, Berlin, Germany , Richter, Rolf Department of Gynecology - Campus Virchow Klinikum - Charit ́eUniversit ̈atsmedizin Berlin, Berlin, Germany , Dragun, Duska Department of Nephrology and Intensive Care Medicine - Charit ́eUniverst ̈atsmedizin Berlin, Berlin, Germany , Heidecke, Harald CellTrend, Luckenwalde, Germany , Dechend, Ralf Experimental and Clinical Research Center, Berlin, Germany , Muller, Dominik N. Experimental and Clinical Research Center, Berlin, Germany , Sehouli, Jalid Department of Gynecology - Campus Virchow Klinikum - Charit ́eUniversit ̈atsmedizin Berlin, Berlin, Germany , Braicu, Elena I. Department of Gynecology - Campus Virchow Klinikum - Charit ́eUniversit ̈atsmedizin Berlin, Berlin, Germany
Abstract :
Aim. The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC). As part of the renin-angiotensin system (RAS) whose activity is known to increase in ovarian cancer patients, the relation of sPRR and ovarian cancer should be further investigated. Patients and Methods. In this study 197 patients with primary EOC in our institution from 2000 to 2011 were included. sPRR was determined by enzyme-linked immunosorbent assay (ELISA) in preoperative taken blood sera. Associations with clinicopathological outcome were analyzed and serum levels of sPRR in patients have been compared to those in healthy specimen. Kaplan-Meier and logistic/Cox regression assessed the impact of the markers on progression-free survival (PFS) and overall survival (OS). Results. There have been no correlations proved of sPRR levels with neither clinicopathological factors nor prognostic data. Also the distribution of sPRR in patients and controls was normal. Conclusion. sPRR seems to have no predictive, prognostic, or diagnostic value in EOC. As several factors of the RAS which might indicate cancer events have been shown, sPRR seems not to be affected.
Keywords :
Ovarian Cancer , Primary Epithelial , Prognostic Value , sPRR
