Title of article :
Epidermal Growth Factor Receptor Gene in Non-Small-Cell LungCancer: The Importance of Promoter Polymorphism Investigation
Author/Authors :
Jurišić, Vladimir Faculty of Medical Sciences - University of Kragujevac - Svetozara Markovica, Kragujevac, Serbia , Obradovic, Jasmina institute of Biology and Ecology - Faculty of Science - University of Kragujevac, Radoja Domanovica, Kragujevac, Serbia , Pavlović, Sonja Institute of Molecular Genetics and Genetic Engineering - University of Belgrade - Vojvode Stepe, Belgrade, Serbia , Djordjevic, Nataša Faculty of Medical Sciences - University of Kragujevac - Svetozara Markovica, Kragujevac, Serbia
Abstract :
Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of lung cancer, and it was a target for a newtherapeutic strategy, based on molecular analyses. In this review, we have summarized some issues considering the role of EGFR inlung cancer, its coding gene, and its promoter gene polymorphisms (SNPs) -216G/T and -191C/A in non-small-cell lung cancer(NSCLC). The position of the SNPs indicates their significant role in EGFR regulation. The accumulation of knowledgeregarding SNPs lately suggests their significant and important role in the onset of carcinogenesis, the prediction of the onset ofmetastases, the response to therapy with TKI inhibitors, and the onset of toxic effects of the applied therapy. Based on this, wesuggest further studies of the relationship of clinical significance to SNPs in patients with lung tumors.
Farsi abstract :
فاقد چكيده فارسي
Keywords :
Non-Small-Cell LungCancer , Promoter Polymorphism , Epidermal Growth , gene
Journal title :
Analytical Cellular Pathology
