Cytotoxicity and Antiangiogenic Activity ofTurbinaria ornataAgardh andPadina australisHauck Ethanolic Extracts

Brown macroalgae species are constantly reported as potential sources of bioactive compounds useful in inhibiting cellproliferation and vascular formation. Thus, this study was conducted to determine and compare thein vitrocytotoxicactivities ofTurbinaria ornataAgardh andPadina australisHauck ethanolic extracts against baker’s yeast (Saccharomycescerevisiae) using the resazurin reduction test (RRT) and investigate theirin vivoantiangiogenic activity through duck(Anas platyrhynchos) chorioallantoic membrane (CAM) assay. BothT. ornataandP. australisethanolic extracts exhibitedcytotoxic activities at IC50of 530.53 ppm and 528.78 ppm, respectively, and significant cytotoxicity was determined in750 ppm and 1000 ppm concentrations ofT. ornataand 1000 ppm concentration ofP. australis. Also, bothT. ornataandP. australisethanolic extracts exhibited antiangiogenic activity (100% vascular inhibition) as all the concentrations of bothspecies caused severe vascular damage in all the duck CAM samples treated. These results show the potential futureapplication of these species for cytotoxic activities and vascular inhibition. The conduct of further tests using other modelsystems is recommended.