Author/Authors :
Na, Buqi Department of Respiratory and Critical Care Medicine - Beijing Jishuitan Hospital, Beijing, China , Zhang, Hong Department of Respiratory and Critical Care Medicine - Peking University First Hospital, Beijing, China , Wang, Guangfa Department of Respiratory and Critical Care Medicine - Peking University First Hospital, Beijing, China , Dai, Li Department of Respiratory and Critical Care Medicine - Beijing Jishuitan Hospital, Beijing, China , Xia, Guoguang Department of Respiratory and Critical Care Medicine - Beijing Jishuitan Hospital, Beijing, China
Abstract :
Background and Objective. TWIK-related acid-sensitive potassium channel 1 (TASK-1) is closely related to respiratory central
control and neuronal injury. We investigated the effect of MV on TASK-1’s functions and explored the mechanism using a rat
model. Methods. Male Sprague-Dawley rats were randomized to three groups: (1) high tidal volume (HVt): MV for four hours with
Vt at 10 mL/kg; (2) low Vt (LVt): MV for four hours with Vt at 5 mL/kg; (3) basal (BAS): anesthetized and unventilated animals.
We measured lung histology and plasma and brain levels of proteins (IL-6, TNF-𝛼, and S-100B) and determined TASK-1 levels
in rat brainstems as a marker of respiratory centre activity. Results. The LISs (lung injury scores) were significantly higher in the
HVt group. Brain inflammatory cytokines levels were different to those in serum. TASK-1 levels were significantly lower in the MV
groups (𝑃 = 0.002) and the HVt group tended to have a lower level of TASK-1 than the LVt group. Conclusion. MV causes not only
lung injury, but also brain injury. MV affects the regulation of the respiratory centre, perhaps causing damage to it. Inflammation
is probably not the main mechanism of ventilator-related brain injury.
