Author/Authors :
Borja-Flores, Adri ́an HGZ 5 Con MF - Delegaci ́on Estatal Morelos - Zacatepec - Morelos, Mexico , Reyes-Mart ́ınez, Eloy HGZ 5 Con MF - Delegaci ́on Estatal Morelos - Zacatepec - Morelos, Mexico , Belzazar-Castillo de la Torre, Jos ́e HGZ 5 Con MF - Delegaci ́on Estatal Morelos - Zacatepec - Morelos, Mexico , Mac ́ıas-Hern ́andez, Salvador I. Orthopedic Rehabilitation Division - Instituto Nacional de Rehabilitaci ́on Luis Guillermo Ibarra - Mexico City, Mexico , Hern ́andez-Molina, Gabriela Department of Immunology and Rheumatology - Instituto Nacional de Ciencias M ́edicas y Nutrici ́on Salvador Zubir ́an - Mexico City, Mexico , Furuzawa-Carballeda, Janette Department of Immunology and Rheumatology - Instituto Nacional de Ciencias M ́edicas y Nutrici ́on Salvador Zubir ́an - Mexico City, Mexico , Perez-Ortiz, Andric Escuela de Medicina - Universidad Panamericana - Donatello 59 - Insurgentes Mixcoac - Benito Juárez - Mexico City, Mexico , Laura ́Avila-Jim ́enez, Coordinaci ́on de Planeaci ́on y Enlace Institucional - Jefatura de Servicios de Prestaciones M ́edicas - Delegaci ́on Estatal Morelos - Cuernavaca - Morelos, Mexico , V ́azquez-Bello, Mar ́ıa Cristina Coordinaci ́on de Planeaci ́on y Enlace Institucional - Jefatura de Servicios de Prestaciones M ́edicas - Delegaci ́on Estatal Morelos - Cuernavaca - Morelos, Mexico , Le ́on-Maz ́on, Marco Antonio Centro de Investigaci ́on Educativa y Formaci ́on Docente - Coordinaci ́on de Planeaci ́on y Enlace Institucional,Jefatura de Servicios de Prestaciones M ́edicas - Delegaci ́on Estatal Morelos - Cuernavaca - Morelos, Mexico , Torres-Villalobos, Gonzalo Departments of Experimental Surgery and Surgery - Instituto Nacional de Ciencias M ́edicas y Nutrici ́on Salvador Zubir ́an - Mexico City, Mexico , Romero-Hern ́andez, Fernanda Departments of Experimental Surgery and Surgery - Instituto Nacional de Ciencias M ́edicas y Nutrici ́on Salvador Zubir ́an - Mexico City, Mexico , Albavera-Hern ́andez, Cidronio Centro de Investigaci ́on Educativa y Formaci ́on Docente - Coordinaci ́on de Planeaci ́on y Enlace Institucional,Jefatura de Servicios de Prestaciones M ́edicas - Delegaci ́on Estatal Morelos - Cuernavaca - Morelos, Mexico , Jes ́us P ́erez-Correa, Department of Traumatology and Orthopedics - Hospital “Dr. Victorio de la Fuente Narv ́aez” - Mexico City, Mexico , Castro-Rocha, Hilda A. Siracusa No. 51 Col. Lomas Estrella - Mexico City, Mexico
Abstract :
Polymerized-type I collagen (polymerized-collagen) is a downregulator of inflammation and a tissue regenerator. /e aim wasto evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis(OA) in delaying or preventing joint replacement surgery.Patients and Methods. /is was a cohort study of 309 patients with knee OA.Patients with mild-to-moderate disease were treated weekly with IAIs of 2 mL of polymerized-collagen for six weeks (n�309). Follow-upwas for 6–60 months. /e primary endpoints included the following determinations: (1) therapeutic effect; (2) survival from total kneereplacement surgery (TKR); (3) Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and pain (visual analoguescale, VAS). Clinical improvement was defined as a decrease in pain exceeding 20 mm on the VAS and the achievement of at least 20%improvement from baseline with respect to the WOMAC score. Radiographic analysis was performed at baseline and 60 months. /ejoint space width in the medial, lateral, and patellofemoral compartments was calculated.Results. Patients who received IAIs of po-lymerized-collagen had a statistically significant improvement in the primary criteria (p<0.05). Kaplan–Meier survival analysis of thetherapeutic effect demonstrated 98.8% survival at 60 months with TKR as the endpoint. /ere was no significant reduction in joint spacein any compartment based on the analyzed radiographs. No serious adverse events were recorded.Conclusion. Polymerized-collagenincreased the time to TKR by at least 60 months, modifying the disease course, improving functional disability, and decreasing pain
Keywords :
Long-Term Effectiveness , Polymerized-Type I CollagenIntra-Articular Injections , Patients , Symptomatic KneeOsteoarthritis , Clinical and Radiographic Evaluation , Cohort Study
