Author/Authors :
Zhang, Fan Department of Cardiothoracic Surgery - Affiliated Hangzhou First People’s Hospital - Zhejiang University School of Medicine, China , Meng, Jingfei The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China , Jiang, Hong Department of Cardiothoracic Surgery - Affiliated Hangzhou First People’s Hospital - Zhejiang University School of Medicine, China , Feng, Xing Department of Cardiothoracic Surgery - Affiliated Hangzhou First People’s Hospital - Zhejiang University School of Medicine, China , Wei, Dongshan Department of Cardiothoracic Surgery - Affiliated Hangzhou First People’s Hospital - Zhejiang University School of Medicine, China , Meng, Wen Department of Cardiothoracic Surgery - Affiliated Hangzhou First People’s Hospital - Zhejiang University School of Medicine, China
Abstract :
The expression of G2 and S phase-expressed-1 (GTSE1) was upregulated in human cancer. However, its expression and roles inlung cancer have not been identified yet. In our study, we reported that GTSE1 expression was statistically higher in lung tissuesthan in the adjacent noncancerous tissues which might be a consequence of hypomethylation of the GTSE1 promoter. Theupregulated expression of GTSE1 mRNA predicted the poorer survival of the lung patients. Ectopic expression of GTSE1 inlung cancer cells significantly increased while knockdown of GTSE1 decreased cell proliferation, cell migration, and cell invasionin H460 and A549 cells. Furthermore, knockdown of GTSE1 regulated the cell cycle and promoted cell apoptosis in H460 andA549 cells. Finally, we presented that GTSE1 was able to activate AKT/mTOR signaling in H460 and A549 cells. In conclusion,these results indicated that the over expressed GTSE1 was involved in the progress of lung cancer by promoting prolife rationmigration and invasion and inhibiting apoptosis of lung cancer cells via activating AKT/mTOR signaling.
