Author/Authors :
Wu, Ping Department of Anesthesiology - The First Affiliated Hospital of Dalian Medical University, Dalian, China , Xu, Yingkun Department of Urology - Shandong Provincial Hospital - Cheeloo College of Medicine - Shandong University, Jinan, China , Li, Jiayi School of Business - Hanyang University, Seoul, Republic of Korea , Li, Xiaowei Department of Urology - The First Affiliated Hospital of Dalian Medical University, Dalian, China , Zhang, Peizhi Department of Urology - Shandong Provincial Hospital - Cheeloo College of Medicine - Shandong University, Jinan, China , Ruan, Ningke The Nursing College of Zhengzhou University, Zhengzhou, China , Zhang, Cong Department of Pain Management, Shandong Provincial Hospital - Cheeloo College of Medicine - Shandong University, Jinan, China , Sun, Panpan Department of Pain Management - The Second Hospital of Shandong University, Jinan, China , Wang, Qifei Department of Urology - The First Affiliated Hospital of Dalian Medical University, Dalian, China , Wu, Guangzhen Department of Urology - The First Affiliated Hospital of Dalian Medical University, Dalian, China
Abstract :
This study analyzed and compared the potential role of fatty acid metabolism pathways in three subtypes of renal cell carcinoma.Biological pathways that were abnormally up- and downregulated were identified through gene set variation analysis in the subtypes. Abnormal down regulation of the fatty acid metabolism pathway occurred in all three renal cell carcinoma subtypes.Alteration of the fatty acid metabolism pathway was vital in the development of pan-renal cell carcinoma. Bioinformaticsmethods were used to obtain a panoramic view of copy number variation, single-nucleotide variation, mRNA expression, andthe survival landscape of fatty acid metabolism pathway-related genes in pan-renal cell carcinoma. Most importantly, we usedgenes related to the fatty acid metabolism pathway to establish a prognostic-related risk model in the three sub types of renal cell carcinoma. The data will be valuable for future clinical treatment and scientific research
