Title of article :
Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites
Author/Authors :
Li, Qigui Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Xie, Lisa Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Caridha, Diana Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Zeng, Qiang Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Zhang, Jing Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Roncal, Norma Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Zhang, Ping Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Vuong, Chau Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Potter, Brittney Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Sousa, Jason Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Marcsisin, Sean Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Read, Lisa Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA , Hickman, Mark Military Malaria Research Program - Walter Reed Army Institute of Research - Experimental Therapeutics Branch, Silver Spring, MD, USA
Pages :
10
From page :
1
To page :
10
Abstract :
Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were conducted at various single intramuscular-decoquinate doses for 2, 4, 6, or 8 weeks prior to infection with P. berghei sporozoites. The liver stage efficacy evaluation was monitored by using an in vivo imaging system. Full causal prophylaxis was shown in mice with a single intramuscular dose at 120 mg/kg of nanoparticle decoquinate (0.43 𝜇m) for 2-3 weeks and with microparticle decoquinate (8.31 𝜇m) injected 8 weeks earlier than inoculation. The time above MIC of 1,375 hr observed with the microparticle formulation provided a 2.2-fold longer drug exposure than with the nanoparticle formulation (624 hr). The prophylactic effect of the microparticle formulation observed in mice was shown to be 3-4 times longer than the nanoparticle decoquinate formulation.
Farsi abstract :
فاقد چكيده فارسي
Keywords :
Long-Term Prophylaxis , Pharmacokinetic Evaluation , Nano- and Microparticle Decoquinate , P. berghei Sporozoites
Journal title :
Malaria Research and Treatment
Serial Year :
2017
Full Text URL :
downloads.hindawi.com/archive/2017/7508291.pdf
Record number :
2606176
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2606176
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