Author/Authors :
Zou, Fenfang Department of Respiratory - The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, China , Zhang, Jianpeng Department of Respiratory - The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, China , Xiang, Guoan Department of Respiratory - The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, China , Jiao, Hongbin Department of Respiratory - The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, China , Gao, Hongmei Department of Respiratory - The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, China
Abstract :
Published data on the association between MMP-9 polymorphisms (−1562 C > T, rs3918242; Gln279Arg, rs17576
Arg668Gln, rs17577) and asthma susceptibility are inconclusive. To derive a more precise estimation of this association, a
meta-analysis was performed. A literature search was conducted in PubMed, Web of Science, EMBASE, Wanfang, and
China National Knowledge Infrastructure (CNKI) databases to identify eligible studies. .e pooled odds ratios (ORs) and
corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was
performed to evaluate the influence of individual studies on the overall effect estimates, and funnel plots and Egger’s test
were inspected for indication of publication bias. Seven studies with 1592 asthma patients and 1987 controls were finally
identified. Overall, we found no significant association between −1562 C > T, rs3918242 polymorphism, and asthma
susceptibility in any of the genetic model comparisons. After categorizing studies into different subgroups on the basis of
ethnicity and age, there is still no significant association. For the Gln279Arg, rs17576 polymorphism, there seems to be a
significant association in the allelic genetic model in regard to the P value (OR = 1.11, 95% CI = 1.00–1.22, I
2 = 0%,
P(Z) = 0.044); however, the value of lower 95% CI is 1.0. For the Arg668Gln, rs17577 polymorphism, a high significant
association was observed in the dominant model comparison (OR = 1.65, 95% CI = 1.28–2.11, I
2 = 22.50%, P(Z) = 0),
recessive model comparison (OR = 2.40, 95% CI = 1.23–4.72, I
2 = 0%, P(Z) = 0.011), homozygote genotype comparison
(OR = 2.69, 95% CI = 1.36–5.33, I
2 = 0%, P(Z) = 0.004), and allelic genetic model (OR = 1.59, 95% CI = 1.29–1.97, I
2 = 36.9%,
P(Z) = 0). Sensitivity analysis demonstrated the stability of our results, and publication bias was not evident. .e present
meta-analysis suggests that MMP-9 Arg668Gln, rs17577 polymorphism may be the risk factor for asthma susceptibility.
