Author/Authors :
Niemeier, Janet P Carolinas Medical Center, Charlotte, USA , Perrin, Paul B Department of Psychology - Virginia Commonwealth University, Richmond, USA , Hurst, Bradley S Carolinas Medical Center, Charlotte, USA , Foureau, David M. Carolinas Medical Center, Charlotte, USA , Huynh, Toan T Carolinas Medical Center, Charlotte, USA , Evans, Susan L Carolinas Medical Center, Charlotte, USA , Silverman, Jonathan E Carolinas Medical Center, Charlotte, USA , McClannahan, M. Elise Carolinas Medical Center, Charlotte, USA , Brusch, Benjamin D Carolinas Medical Center, Charlotte, USA , Newman, Mark Carolinas Medical Center, Charlotte, USA , Mougeot, Jean-Luc Carolinas Medical Center, Charlotte, USA , Wagner, Amy K Carolinas Medical Center, Charlotte, USA
Abstract :
Objective. To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting.
Hospital emergency department. Participants. 21 women ages 18-35 with TBI and 21 controls. Design. Repeated measures. Main
Measures. Serum samples at baseline and 72 hours; immunoassays for estradiol (E2), progesterone (PRO), luteinizing hormone
(LH), follicle-stimulating hormone (FSH), and cortisol (CORT); and health history. Results. Women with TBI had lower E2
(p = 0 042) and higher CORT (p = 0 028) levels over time. Lower Glasgow Coma Scale (GSC) and OCs were associated with
lower FSH (GCS p = 0 021; OCs p = 0 016) and higher CORT (GCS p = 0 001; OCs p = 0 008). Conclusion. Acute TBI may
suppress E2 and increase CORT in young women. OCs appeared to independently affect CORT and FSH responses. Future
work is needed with a larger sample to characterize TBI effects on women’s endogenous hormone response to injury and OC
use’s effects on post-TBI stress response and gonadal function, as well as secondary injury
Keywords :
Repeated Measures , Pilot Comparison , Trajectories , Fluctuating Endogenous Hormones , Traumatic Brain Injury
