Author/Authors :
Xie, Yi Department of Prevention - Haihe Hospital - Tianjin University, Tianjin, China , Han, Jing Department of Medical Administration - Haihe Hospital, Tianjin University, Tianjin, China , Yu, Weili Department of Prevention - Haihe Hospital - Tianjin University, Tianjin, China , Wu, Junping Tianjin Key Laboratory of Lung Regenerative Medicine, Tianjin, China , Li, Xue Tianjin Key Laboratory of Lung Regenerative Medicine, Tianjin, China , Chen, Huaiyong Tianjin Key Laboratory of Lung Regenerative Medicine, Tianjin, China
Abstract :
Identify the treatment effects and risk factors for mortality in patients with pulmonary tuberculosis receiving antituberculosis
treatment under the Directly Observed Treatment Short-Course (DOTS) program to reduce the mortality rate of tuberculosis. A
retrospective cohort analysis was conducted on the outcomes of antituberculosis treatment of 7,032 patients with tuberculosis in
the DOTS program, in the Tuberculosis Management Information System from 2014 to 2017 in Tianjin, China. The Kaplan–Meier
method and multifactor Cox proportional risk regression model were used to analyze the risk factors for mortality during
antituberculosis treatment under DOTS. )e success rate of antituberculosis treatment was 90.24% and the mortality rate was
4.56% among 7,032 cases of tuberculosis in Tianjin. Cox regression analysis showed that advanced age, male sex, human
immunodeficiency virus (HIV) positivity, first sputum positivity, retreated tuberculosis, and a delayed visit (≥14 days) were risk
factors for mortality in patients with pulmonary tuberculosis receiving antituberculosis treatment under DOTS. )e treatment
effects in patients with pulmonary tuberculosis during antituberculosis treatment under DOTS were positive in Tianjin. Advanced
age, male sex, HIV positivity, first sputum positivity, retreated tuberculosis, and a delayed visit (≥14 days) increased the risk for
mortality during antituberculosis treatment.
