Title of article
An Analytical Study of Prostate-Specific Antigen Dynamics
Author/Authors
Esteban, Ernesto P Physics Department - University of Puerto Rico-Humacao - Jose E. Aguiar Avenue - Humacao, USA , Deliz, Giovanni Biology Department - University of Puerto Rico-Humacao - Jose E. Aguiar Avenue - Humacao, USA , Rivera-Rodriguez, Jaileen Biology Department - University of Puerto Rico-Humacao - Jose E. Aguiar Avenue - Humacao, USA , Laureano, Stephanie M Biology Department - University of Puerto Rico-Humacao - Jose E. Aguiar Avenue - Humacao, USA
Pages
6
From page
1
To page
6
Abstract
The purpose of this research is to carry out a quantitative study of prostate-specific antigen dynamics for patients with prostatic
diseases, such as benign prostatic hyperplasia (BPH) and localized prostate cancer (LPC). The proposed PSA mathematical model
was implemented using clinical data of 218 Japanese patients with histological proven BPH and 147 Japanese patients with LPC
(stages T2a and T2b). For prostatic diseases (BPH and LPC) a nonlinear equation was obtained and solved in a close form to
predict PSA progression with patients’ age. The general solution describes PSA dynamics for patients with both diseases LPC and
BPH. Particular solutions allow studying PSA dynamics for patients with BPH or LPC. Analytical solutions have been obtained
and solved in a close form to develop nomograms for a better understanding of PSA dynamics in patients with BPH and LPC. This
study may be useful to improve the diagnostic and prognosis of prostatic diseases.
Keywords
Prostate-Specific , LPC , BPH
Journal title
Computational and Mathematical Methods in Medicine
Serial Year
2016
Full Text URL
Record number
2606411
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