Author/Authors :
Liu, Jinzhi Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , Si, Zhihua Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , Liu, Jie Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , Lin, Yan Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , Yuan, Jing Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , Xu, Shan Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , He, Yan Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , Zhang, Tao Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China , Wang, Aihua Department of Neurology - Shandong Provincial Qianfoshan Hospital - The First Affiliated Hospital of Shandong First Medical University, Jinan, China
Abstract :
Objective. To study the clinical manifestations, magnetic resonance imaging (MRI) findings, and prognosis of delayed
encephalopathy after carbon monoxide poisoning (DEACMP). Methods. The medical records of 20 patients with DEACMP
were retrospectively reviewed. All the patients received hyperbaric oxygen treatment and other treatments as necessary. Results.
The patients had diverse clinical manifestations, including memory deficits, personality changes, cognitive or executive function
deficits, mood disorders, Parkinsonism, dystonia or other motor impairments, and akinetic mutism. MRI revealed lesions in the
bilateral cerebral white matter and/or basal ganglia. Except for the pathologically confirmed DEACMP, epileptic seizure,
hemiplegia, and vegetative state, the remaining symptoms had been improved, especially the cognitive impairment, which had
been decreased from 95% to 25% and psychiatric symptoms also decreased from 95% to 55% at the 6-month follow-up.
Conclusions. The prognosis of patients with DEACMP was poor, and they had a relatively severe disability. The early use of
hyperbaric oxygen is of great significance to improve clinical efficacy and get a better prognosis.
Keywords :
Prognosis , Delayed Encephalopathy , Acute Carbon , Monoxide Poisoning
