Isoniazid-Induced Acute Psychosis in a Patient withPleural Tuberculosis

Tuberculosis is one of the top 10 causes of death and the leading cause from a single infectious agent (above HIV/AIDS). Isoniazidis highly bactericidal against replicating tubercle bacilli and is a component of all antituberculous chemotherapeutic regimenscurrently recommended by the World Health Organization (WHO). Several neuropsychiatric adverse effects, following boththerapeutic and overdose use of isoniazid, have been described and isoniazid-induced psychosis, although uncommon, has beenreported in the literature. We describe the case of a 21-year-old black woman, with no prior psychiatric history, who developed apsychotic episode four days after she was started on isoniazid. This case highlights psychosis arising as a possible adverse effect ofisoniazid and the importance of remaining vigilant when antituberculous therapy is started.