Author/Authors :
Zhang, Cheng Department of Respiratory and Critical Care Medicine - Peking University First Hospital, Beijing, China , Chen, Kun Academy of Advanced Interdisciplinary Studies - Peking University, Beijing, China , Wang, Guangfa Department of Respiratory and Critical Care Medicine - Peking University First Hospital, Beijing, China , Zhang, Jue Academy of Advanced Interdisciplinary Studies - Peking University, Beijing, China , Ma, Jing Department of Respiratory and Critical Care Medicine - Peking University First Hospital, Beijing, China
Abstract :
,is study aimed to investigate the effects of continuous positive airway pressure (CPAP) on the electroencephalographic (EEG)
characteristics of patients with primary central sleep apnea syndrome (CSAS). Nine patients with primary CSAS were enrolled in
this study. The raw sleep EEG data were analyzed based on two main factors: fractal dimension (FD) and zero-crossing rate of
detrended FD. Additionally, conventional EEG spectral analysis in the delta, theta, alpha, and beta bands was conducted using a
fast Fourier transform. The FD in patients with primary CSAS who underwent CPAP treatment was significantly decreased during
nonrapid eye movement (NREM) sleep but increased during rapid eye movement (REM) sleep (p < 0.05). Regarding the EEG
spectral analysis, the alpha power increased, while the delta/alpha ratio decreased during REM sleep in patients with CSAS
(p < 0.05). In conclusion, CPAP treatment can reduce FD in NREM sleep and increase FD during REM sleep in patients with
primary CSAS. FD may be used as a new biomarker of EEG stability and improvement in brain function after CPAP treatment for
primary CSAS.
