Author/Authors :
Roth, Michael Pulmonary Cell Research - DBM University Basel and Pneumology Clinic - University Hospital Basel, Basel, Switzerland , Khameneh, Hanif J. Institute for Research in Biomedicine - Faculty of Biomedical Sciences - Universita Della Svizzera Italiana, Bellinzona, Switzerland , Fang, Lei Pulmonary Cell Research - DBM University Basel and Pneumology Clinic - University Hospital Basel, Basel, Switzerland , Tamm, Michael Pulmonary Cell Research - DBM University Basel and Pneumology Clinic - University Hospital Basel, Basel, Switzerland , Rossi, Giovanni A. Department of Pediatrics Pulmonology and Allergy Units - IRCCS Istituto Giannina Gaslini, Genoa, Italy
Abstract :
Oral bacterial lysates (OBLs) can reduce the frequency and severity of recurrent respiratory tract infections in children from viral and
bacterial origins. OBL-induced early innate immune reaction was already shown, but the specific features of different OBLs have never
been studied and compared. A study was conducted to assess in vitro the protective effects on rhinovirus- (RV-) infected human
bronchial epithelial cells (BECs) of two slightly different OBLs: OM-85 and Pulmonarom. Furthermore, since immune cells represent
the key arm for antiviral defence, the capacity of these OBLs to induce selected cytokine production in mouse bone marrow-derived DCs
(BMDCs) was also evaluated. Although different OBLs may share some mechanisms to protect host cells from virus infection, some
product-specific antimicrobial activities were observed on RV-infected human BECs and mouse BMDCs. These results are consistent
with a product-specific response possibly triggered by different pathogen-associated molecular patterns (PAMPs) contained in OBLs.
