Author/Authors :
Ye, Hanhui Mengchao Hepatobiliary Hospital of Fujian Medical University - Fuzhou, China , Yuan, Jinjin Mengchao Hepatobiliary Hospital of Fujian Medical University - Fuzhou, China , Wang, Zhengwu Mengchao Hepatobiliary Hospital of Fujian Medical University - Fuzhou, China , Huang, Aiqiong Mengchao Hepatobiliary Hospital of Fujian Medical University - Fuzhou, China , Liu, Xiaolong Mengchao Hepatobiliary Hospital of Fujian Medical University - Fuzhou, China , Han, Xiao Biotechnology Research Institute - Chinese Academy of Agricultural Sciences - Beijing, China , Chen, Yahong Mengchao Hepatobiliary Hospital of Fujian Medical University - Fuzhou, China
Abstract :
Human immunodeficiency virus causes a severe disease in humans, referred to as immune deficiency syndrome. Studies on the
interaction between host genetic factors and the virus have revealed dozens of genes that impact diverse processes in the AIDS
disease. To resolve more genetic factors related to AIDS, a canonical correlation analysis was used to determine the correlation
between AIDS restriction and metabolic pathway gene expression. The results show that HIV-1 postentry cellular viral cofactors
from AIDS restriction genes are coexpressed in human transcriptome microarray datasets. Further, the purine metabolism pathway
comprises novel host factors that are coexpressed with AIDS restriction genes. Using a canonical correlation analysis for expression
is a reliable approach to exploring the mechanism underlying AIDS.
Keywords :
AIDS , Cooperator , Metabolism , Pathways
