Title of article :
Delayed-Onset Seizure in a Mild Quetiapine Overdose:Report of a Case and Review of the Literature
Author/Authors :
Cheung, Erick H. Department of Psychiatry and Biobehavioral Sciences - UCLA David Geffen School of Medicine - Los Angeles - CA , USA , Chen, Jason A. Department of Psychiatry and Biobehavioral Sciences - UCLA David Geffen School of Medicine - Los Angeles - CA , USA , Unverferth, Katherine M. Department of Psychiatry and Biobehavioral Sciences - UCLA David Geffen School of Medicine - Los Angeles - CA , USA
Abstract :
Among atypical antipsychotics, quetiapine is commonly prescribed and considered to have a favorable side effect and safety profile.Here, we report the case of a patient who developed a generalized tonic-clonic seizure 28 hours following ingestion of 1,400 mg ofquetiapine. Review of the literature identifies delayed-onset seizure as a potential complication of quetiapine overdose. Uniqueto this case, delayed-onset seizures occurred in a patient with a relatively low dose of quetiapine and no obvious toxidrome,suggesting that this reaction may be an important consideration in the management of quetiapine overdose. The pharmacokineticsand pharmacodynamics of quetiapine may explain this unusual phenomenon
Keywords :
Delayed-Onset Seizure , Mild Quetiapine Overdose
Journal title :
Case Reports in Psychiatry
