Author/Authors :
Tichanon, Promsrisuk Department of Physiology- Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand , Wilaiwan, Khrisanapant Department of Physiology- Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand , Sopida, Santamit Department of Physiology- Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand , Orapin, Pasurivong Department of Physiology- Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand , Watchara, Boonsawat Department of Medicine - Faculty of Medicine - Khon Kaen University, Khon Kaen, Thailand , Banjamas, Intarapoka Bumrungrad International Hospital, Bangkok, Thailand
Abstract :
Background. Airway inflammation and oxidative stress may be linked in obstructive sleep apnea (OSA) patients. We determined
the effectiveness of continuous positive airway pressure (CPAP) therapy in reducing fractional exhaled nitric oxide (FeNO) and
malondialdehyde (MDA) levels in OSA patients. Methods.Thirteen patients with OSA and 13 normal controls were recruited. FeNO
and MDA levels were measured in the controls and in OSA patients before and after three months of CPAP therapy. Results. FeNO
and MDA levels were higher in the patients compared to the age and gender matched controls (FeNO: 25.9 ± 5.0 versus 17.5 ±
5.9 ppb, 𝑃 < 0.001; MDA: 14.6 ± 7.8 versus 2.1 ± 0.3 𝜇mol/L, 𝑃 < 0.001). FeNO and MDA levels were lower post-CPAP compared to
pre-CPAP (FeNO: 25.9 ± 5.0 versus 17.0 ± 2.3 ppb, 𝑃 < 0.001; MDA: 14.6 ± 7.8 versus 10.0 ± 6.4 𝜇mol/L, 𝑃 < 0.01). Apnea-hypopnea
index (15.9 ± 6.6 versus 4.1 ± 2.1/h, 𝑃 < 0.001) and mean arterial pressure (𝑃 < 0.01) decreased following CPAP treatment. Daytime
mean SpO2 (𝑃 < 0.05) increased. Conclusion. Our study demonstrates that CPAP therapy yields clinical benefits by reducing upper
airway inflammation and oxidative stress in OSA patients.
Keywords :
Positive Airway Pressure , Airway Inflammation , Oxidative , Obstructive Sleep Apnea
