Phenibut (𝛽-Phenyl-𝛾-aminobutyric Acid) Dependence andManagement of Withdrawal: Emerging Nootropics of Abuse

This case report describes the development of withdrawal from phenibut, a gamma-aminobutyric acid-receptor type B agonist.Although phenibut is not an FDA-approved medication, it is available through online retailers as a nootropic supplement. Thereare reports of dependence in patients that misuse phenibut. We report a case in which a patient experienced withdrawal symptomsfrom phenibut and was successfully treated with a baclofen taper. This case report highlights the development of phenibut usedisorder with coingestion of alcohol and potential management for phenibut withdrawal. We believe clinicians must be aware ofhow phenibut dependence may present and how to manage the withdrawal syndrome