Treatment of Generalized Anxiety Disorder with Gabapentin

Gabapentin is frequently used in the treatment of anxiety disorders. However, there are no randomized controlled trials on theeffectiveness of this medication in generalized anxiety disorder (GAD), and there are only a few case reports. We present a caseof a 59-year-old female with a psychiatric history of GAD. The patient discontinued benzodiazepines after more than 7 years ofdaily treatment which led to rebound anxiety, benzodiazepine withdrawal symptoms, and suicidal ideation. She was psychiatricallyhospitalized and started on gabapentin. Over the next 10 months of outpatient follow-up, she attempted to taper off gabapentindue to personal preference to limit medications. During this time, we observed a clear dose-response pattern of gabapentin onGAD symptoms. In the absence of controlled studies, these findings may offer important information about the effectiveness ofgabapentin in GAD.