Title of article :
Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
Author/Authors :
Li, Pen Department of Medicine - University of Alberta, Edmonton, Canada , Cheung, Lawrence Department of Medicine - University of Alberta, Edmonton, Canada , Chiu, Brian Department of Laboratory-Medicine and Pathology - University of Alberta, Edmonton, Canada
Abstract :
When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma,
arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history
of Sjogren’s syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). ¨
However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH)
polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.
Keywords :
Lymphoid Tissue , Immunoglobulin , Heavy Chain Molecular Testing
Journal title :
Canadian Respiratory Journal
