Serum TLR9 and NF-κB Biochemical Markers in Patients with Acute Pancreatitis on Admission

Aim. %e aim of this study was to investigate the serum TLR9 and NF-κB levels in patients for the diagnosis and prognostication of AP in the emergency department. Methods. In the current study, we looked at the TLR9 and NF-κB pathways in a cohort of 45 acute pancreatitis patients and compared them with the control group. We also divided the patient groups as mild-moderate or severe and compared the biomarker levels between the groups. Results. Of the patients with acute pancreatitis, 22 (49%) were male and 23 (51%) were female. %e mean age of the patient group was 62 years, with a range of 25–95 years. %e control group consisted of 19 (43.1%) male and 25 (56.9%) female patients. %e serum TLR9 and NF-κB values were significantly higher than those of the control group [1104.44 ± 339.20 vs. 702.08 ± 203.94; p < 0.001 and 8.04 ± 1.76 vs. 4.76 ± 1.13; p < 0.001, respectively]. We found that TLR9 and NF-κB had a significant discriminative ability, while the cutoff value for TLR9 was 950.4, with a sensitivity of 73% and specificity of 93% (p < 0.001), and the cutoff value for NF-κB was 6.32, with a sensitivity of 89% and specificity of 100% (p < 0.001). Conclusion. We demonstrated that the TLR9 and NF-κB pathway is activated in acute pancreatitis and increases the inflammatory process. %is may help to further understand the pathogenesis of disorder, diagnosis, and clinical severity. We proposed that blockage of these inflammatory pathways may play a role in the prevention of the disease progression and development of inflammatory complications.