Title of article
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH
Author/Authors
Wan, Xingyong Department of Gastroenterology - The First Affiliated Hospital - College of Medicine - Zhejiang University, China , Xu, Chengfu Department of Gastroenterology - The First Affiliated Hospital - College of Medicine - Zhejiang University, China , Yu, Chaohui Department of Gastroenterology - The First Affiliated Hospital - College of Medicine - Zhejiang University, China , Li, Youming Department of Gastroenterology - The First Affiliated Hospital - College of Medicine - Zhejiang University, China
Pages
7
From page
1
To page
7
Abstract
Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major public health problem worldwide. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD that may progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of disease progression from NAFLD to NASH has not been fully understood. Immunological mechanisms that have been increasingly recognized in the disease progression include defects in innate immunity, adaptive immunity, Toll-like receptor (TLR) signaling, and gut-liver axis. The NLRP3 inflammasome is an intracellular multiprotein complex involved in the production of mature interleukin 1-beta (IL-1β) and induces metabolic inflammation. NLRP3 inflammasome has been recently demonstrated to play a crucial role in the progression of NASH. This review highlights the recent findings linking NLRP3 inflammasome to the progression of NASH.
Keywords
NLRP3 Inflammasome , NAFLD , NASH
Journal title
Canadian Journal of Gastroenterology and Hepatology
Serial Year
2016
Record number
2607786
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