Author/Authors :
Hu, Yan Department of Geriatrics - Xinhua Hospital of Shanghai Jiaotong University - School of Medicine, Shanghai, China , Chen, Xiaoting Department of Geriatrics - Xinhua Hospital of Shanghai Jiaotong University - School of Medicine, Shanghai, China , Chen, Xiaojing Department of Geriatrics - Xinhua Hospital of Shanghai Jiaotong University - School of Medicine, Shanghai, China , Zhang, Shuang Department of Geriatrics - Xinhua Hospital of Shanghai Jiaotong University - School of Medicine, Shanghai, China , Jiang, Tianyan Department of Geriatrics - Xinhua Hospital of Shanghai Jiaotong University - School of Medicine, Shanghai, China , Chang, Jing Department of Geriatrics - Xinhua Hospital of Shanghai Jiaotong University - School of Medicine, Shanghai, China , Gao, Yanhong Department of Geriatrics - Xinhua Hospital of Shanghai Jiaotong University - School of Medicine, Shanghai, China
Abstract :
Objective. The purpose of this study was to evaluate the effect of bisphosphonates in improving bone mineral density (BMD)
and decreasing the occurrence rate of fractures and adverse events in patients with inflammatory bowel disease (IBD). Methods.
Randomized controlled trials (RCTs) which use bisphosphonates in IBD patients were identified in PubMed, MEDLINE database,
EMBASE database, Web of Knowledge, and the Cochrane Databases between 1990 and June 2016. People received bisphosphonate
or placebos with a follow-up of at least one year were also considered. STATA 12.0 software was used for the meta-analysis.
Results. Eleven randomized clinical trials were included in the meta-analysis. The data indicated that the percentage change in
the increased BMD in the bisphosphonates groups was superior to that of the control groups at the lumbar spine and total hip.
At the femoral neck, there was no significant difference between the two groups. The incidence of new fractures during follow-up
showed significant reduction.The adverse event analysis revealed no significant difference between the two groups. Conclusion. Our
results demonstrate that bisphosphonates therapy has an effect on bone loss in patients with IBD but show no evident efficiency at
increasing the incidence of adverse events.
