Title of article :
A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
Author/Authors :
Tang, Siming Department of Applied Mathematics - School of Mathematics and Physics - University of Science and Technology Beijing - Beijing, China , Ma, Wanbiao Department of Applied Mathematics - School of Mathematics and Physics - University of Science and Technology Beijing - Beijing, China , Bai, Peifan Department of Applied Mathematics - School of Mathematics and Physics - University of Science and Technology Beijing - Beijing, China
Abstract :
The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans.
MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for
MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be
present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model
describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results
show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.
Keywords :
MERS-CoV , Dynamic , MERS
Journal title :
Computational and Mathematical Methods in Medicine
