• Title of article

    Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

  • Author/Authors

    Bromis, Konstantinos School of Electrical and Computer Engineering - National Technical University of Athens - Athens, Greece , Gkiatis, Kostakis School of Electrical and Computer Engineering - National Technical University of Athens - Athens, Greece , Karanasiou, Irene Hellenic Military University - Vari - Athens, Greece , Matsopoulos, George School of Electrical and Computer Engineering - National Technical University of Athens - Athens, Greece , Karavasilis, Eustratios “Evgenidion” General Hospital - Athens, Greece , Papathanasiou, Matilda Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece , Efstathopoulos, Efstathios Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece , Kelekis, Nikolaos Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece , Kouloulias, Vasileios Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece

  • Pages
    12
  • From page
    1
  • To page
    12
  • Abstract
    Previous studies in small-cell lung cancer (SCLC) patients have mainly focused on exploring neurocognitive deficits associated with prophylactic cranial irradiation (PCI). Little is known about functional brain alterations that might occur due to chemotherapy treatment in this population before PCI is administered. For this reason, we used resting-state functional Magnetic Resonance Imaging (fMRI) to examine potential functional connectivity disruptions in brain networks, including the Default Mode Network (DMN), the Sensorimotor Network, and the Task-Positive Network (TPN). Nineteen SCLC patients after platinum-based chemotherapy treatment and thirteen controls were recruited in the current study. ROI-to-ROI and Seed-to-Voxel analyses were carried out and revealed functional connectivity deficits in patients within all the networks investigated demonstrating the possible negative effect of chemotherapy in cognitive functions in SCLC populations.
  • Keywords
    Small-Cell , Brain , Chemotherapy , Resting-State , fMRI
  • Journal title
    Computational and Mathematical Methods in Medicine
  • Serial Year
    2017
  • Full Text URL
    journals/cmmm/2017/1403940.pdf
  • Record number

    2608247

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2608247