Author/Authors :
Martorana, Federica Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Lanzafame, Katia Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Pavone, Giuliana Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Motta, Lucia Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Motta, Gianmarco Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Inzerilli, Nicola Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Carciotto, Rosaria Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Parra, Héctor Josè Soto Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Vigneri, Paolo Division of Medical Oncology-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Via Santa Sofia - Catania - Sicily, Italy , Vecchio, Giada Maria Dept. of Medical and Surgical Sciences and Advanced Technology G. F. Ingrassia-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Catania - Sicily, Italy , Zanghì, Antonino Maria Dept. of Medical and Surgical Sciences and Advanced Technology G. F. Ingrassia-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Catania - Sicily, Italy , Magro, Gaetano Dept. of Medical and Surgical Sciences and Advanced Technology G. F. Ingrassia-A.O.U. Policlinico G. Rodolico-San Marco-Catania - Catania - Sicily, Italy
Abstract :
Intestinal and pancreatic metastases are rare and often challenging to recognize and manage. Lung cancer patients with entericinvolvement usually display poor outcomes. Hyperprogression to immunotherapy represents a concern, even though there iscurrently no agreement on its exact definition. Gastrointestinal hyperprogression to immune checkpoint inhibitors has not beendescribed so far. In these cases, distinguishing disease-related symptoms from immune-related adverse events may represent adiagnostic conundrum. Here, we report two cases of non-small-cell lung cancer experiencing a rapid pancreatic and colicprogression to immunotherapy, respectively. While further investigations to identify biomarkers associated withhyperprogression are warranted, clinicians should be aware of the potential unusual clinical presentations of this phenomenon.
Keywords :
Early Gastrointestinal Progression , Immunotherapy , Lung Cancer , A Report of Two Cases
