Title of article :
Aluminum Oxide Nanoparticle as a Valuable Heterogeneous Nanocatalyst in the Synthesis of 2-Aminothiazole Scaffolds
Author/Authors :
Shokrani, Z. Laboratory of Organic Compound Research - Department of Organic Chemistry - College of Chemistry and Biochemistry - University of Kashan, Kashan, I.R, Iran , Zarnegar, Z. Department of Chemistry - University of Payame Noor, Tehran, Iran , Safari, J. Laboratory of Organic Compound Research - Department of Organic Chemistry - College of Chemistry and Biochemistry - University of Kashan, Kashan, I.R, Iran
Abstract :
An efficient methodology for the preparation of 2-aminothiazoles is achieved by one-pot reaction of methylcarbonyls, thiourea and iodine in the presence of an aluminum oxide nanoparticle as an active nanocatalyst at 85 °C in DMSO solvent. Al2O3 nanoparticles have been prepared via co-precipitation method and their structures were confirmed using Fourier transform infrared radiation (FT-TR), X-ray diffraction (XRD), scanning electron microscopic (SEM), and energy-dispersive analysis of X-ray (EDAX) analyses. Advantages of this efficient synthetic approach include higher purity and excellent yield of products, easy isolation of products and convenient manipulation.
Keywords :
3-Thiazoles , Al2O3 nanoparticles , Methylcarbonyls , One-pot synthesis , Heterogeneous catalyst
Journal title :
Organic Chemistry Research
