Title of article :
Oxaliplatin-Induced Lhermitte’s Sign in Gastric Cancer
Author/Authors :
Fukuda, Katsuyuki Department of Gastroenterology - Chuo-ku - Tokyo , Japan , Okamoto, Takeshi Department of Gastroenterology - Chuo-ku - Tokyo , Japan , Takagi, Koichi Department of Gastroenterology - Chuo-ku - Tokyo , Japan
Abstract :
A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks’duration. He wasdiagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab wasinitiated. During the eighth cycle, he suddenly complained of electric shock-like pain in both legs upon neckflexion, consistentwith Lhermitte’s sign. Oxaliplatin was discontinued, and Lhermitte’s sign resolved after 3 months. Neurotoxicity is commonlyobserved in platinum-based chemotherapy, but Lhermitte’s sign is rare. This is thefirst report of oxaliplatin-induced Lhermitte’ssign in a gastric cancer patient
Keywords :
Oxaliplatin-Induced Lhermitte’s Sign , Gastric Cancer , HER2-positive gastric cancer
Journal title :
Case Reports in Oncological Medicine
