• Title of article

    Intestinal Perforation due to Neutropenic Enterocolitis in aPatient Treated with Bevacizumab for Ovarian Cancer

  • Author/Authors

    Mukohara, Toru Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Sasaki, Akinori Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Harano, Kenichi Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Kogawa, Takahiro Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Matsubara, Nobuaki Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Naito, Yoichi Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Hosono, Ako Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Mukai, Hirofumi Department of Breast and Medical Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan , Yoshino, Takayuki Department of Gastroenterology and Gastrointestinal Oncology - National Cancer Center Hospital East - Kashiwa - Chiba, Japan

  • Pages
    4
  • From page
    1
  • To page
    4
  • Abstract
    Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This reportdescribes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developedneutropenic enterocolitis. A 66-year-old woman diagnosed with metastatic ovarian cancer received combination chemotherapywith carboplatin, gemcitabine, and bevacizumab. On day 14, she developed grade 4 pancytopenia and febrile neutropenia, whichresulted in neutropenic enterocolitis and intestinal perforation. Emergency surgery was performed, and an intestinal perforationfound in the ascending colon was closed. Postoperatively, she developed an intra-abdominal abscess requiring peritonealdrainage. She was discharged from the hospital on recovery.
  • Keywords
    Intestinal Perforation due , Neutropenic Enterocolitis , Patient Treated , Bevacizumab , Ovarian Cancer , VEGF
  • Journal title
    Case Reports in Oncological Medicine
  • Serial Year
    2020
  • Full Text URL
    downloads.hindawi.com/journals/crionm/2020/7231358.pdf
  • Record number

    2608757

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2608757