Author/Authors :
Jouyban, A. tabriz university of medical sciences - Drug Applied Research Center, Faculty of Pharmacy, ايران , Dehghany, M. tabriz university of medical sciences - Liver and Gastrointestinal Diseases Research Center, ايران , Rashidi, M.R. tabriz university of medical sciences - Research Center for Pharmaceutical Nanotechnology, ايران , Dehghan, Gh. university of tabriz - Faculty of Science, تبريز, ايران , Khoubnasabjafari, M. tabriz university of medical sciences - Tuberculosis and Lung Disease Research Center, ايران
Abstract :
A model is proposed to represent the enzyme activity ratios in water – organic solvent mixtures at various temperatures. The prediction capability of the model was evaluated employing aldehyde oxidase as a model enzyme in seven water – organic solvent mixtures at 25, 35 and 45 ˚C by using mean percentage deviation (MPD). The MPD obtained for each water – organic solvent mixture was 6.2%. A general model was also proposed employing the Abraham solvent parameters with MPD as 19.5%. The proposed models could be used in industry for speeding up the process designs where water – organic solvent mixtures at various temperatures were employed.
Keywords :
Enzyme activity , Jouyban , Acree model , Solvent effects , Temperature effects , Abraham solvent parameters
