Author/Authors :
Iuliano, Luigi Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Biancatelli, Ruben Manuel Luciano Colunga Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Ciacciarelli, Marco Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Polidoro, Alessandro Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Clemenzi, Piera Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Congedo, Viviana Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Calvosa, Leonardo Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , D’Armiento, Eleonora Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Misurale, Carmen Department of Medico-Surgical Sciences and Biotechnologies - Internal Medicine Unit - ICOT Hospital - “Sapienza” Universityof Rome - Via Franco Faggiana - Latina, Italy , Bellini, Davide Department of Radiological Sciences - Oncology and Pathology - ICOT Hospital - “Sapienza”University of Rome - Via FrancoFaggiana - Latina, Italy , Badia, Stefano Department of Radiological Sciences - Oncology and Pathology - ICOT Hospital - “Sapienza”University of Rome - Via FrancoFaggiana - Latina, Italy , Mancini, Massimiliano Department of Medico-Surgical Sciences and Biotechnologies - Pathology Unit - ICOT Hospital - “Sapienza”University of Rome,Via Franco Faggiana - Latina, Italy , Petrozza, Vincenzo Department of Medico-Surgical Sciences and Biotechnologies - Pathology Unit - ICOT Hospital - “Sapienza”University of Rome,Via Franco Faggiana - Latina, Italy
Abstract :
Paraneoplastic syndromes are often a diagnostic challenge to doctors and may have a heterogeneous presentation, includinghumoral hypercalcemia of malignancy (HHM), most commonly caused by squamous cell cancer and renal, ovarian,endometrial, and breast cancer. Chronic inflammatory demyelinating polyneuropathy (CIDP) has been described in patientsaffected by several types of cancer, especially hematologic malignancies, and a possible paraneoplastic pathogenesis of thisneurological disease has been suggested. This report describes a 56-year-old man with a history of CIDP diagnosed 3 monthsearlier and persistently elevated aminotransferases for 18 months who was admitted to our internal medicine unit withabdominal pain, fatigue, and severe hypercalcemia with low serum intact parathyroid hormone. Parathyroid hormone-relatedprotein (PTH-rP) was markedly high. Liver imaging showed a large hepatic mass in the right lobe, and percutaneousultrasound-guided biopsy revealed histopathologicalfindings consistent with a combined hepatocholangiocarcinoma (CHCC).We supposed that both HHM and CIDP could represent a paraneoplastic manifestation of CHCC.
Keywords :
Combined Hepatocholangiocarcinoma Associated , Humoral Hypercalcemia , Malignancy , Chronic Inflammatory Demyelinating Polyneuropathy , HHM , CHCC , PTH-rP
