The Review of SARS-CoV-2: Recent Perspective and Advances in Detection

Background: The outbreak of novel coronavirus (2019-nCoV), which began in Wuhan, China, has rapidly spread in many countries and is currently considered a pandemic. The virus (SARS-CoV-2) causes severe acute respiratory syndrome and is related to SARS-CoV and MERS-CoV. Methods: In this review, an introduction to SARS-CoV-2 was provided comprising the following items: general features; pathogenesis; the existing knowledge on immunological properties; transmission routs; diagnostic features, especially discussion about new approaches for treatment and prevention; and different diagnostic methods including nucleic acid based assays, serological testing, and MALDI TOF-MS and LC-MS technologies. Findings and Conclusion: Introducing the different methods for SARS-CoV-2 detection may be useful to provide new insights into the development and improvement of detection primers, probes, methods/techniques, potential targets for drug designation, and therapeutic candidates against the virus.