Title of article :
A Case Presentation of a Patient with Microsatellite Instability andBRAF Mutant Metastatic Colon Cancer and Bibliography update
Author/Authors :
Souglakos, I Department of Medical Oncology - University General Hospital of Heraklion - Heraklion, Greece , Thomopoulou, K Department of Medical Oncology - University General Hospital of Heraklion - Heraklion, Greece , Mavroudis, D Department of Medical Oncology - University General Hospital of Heraklion - Heraklion, Greece , Tzardi, M. Laboratory Department of Pathology - Medical School - University of Crete, Greece
Abstract :
his is a case of a patient who presented to the emergency department with acute abdominal pain due to bowel obstruction. Anextended right hemicolectomy with ileosigmoid anastomosis due to an obstructing mass on the splenicflexure was urgentlyperformed. During operation, liver and peritoneal lesions were detected and samples were also sent for histological analysis.Pathology report was consistent with poorly differentiated mucinous adenocarcinoma with signet ring cells; peritoneal lesionswere confirmed histologically as metastatic. Genetic testing revealed the BRAFV600Emutation and mismatch repair deficiency(dMMR). After progressing on 1st line chemotherapy, the patient has a continuing and long-lasting partial response to 2nd linetreatment with pembrolizumab.
Keywords :
Presentation , Patient , Microsatellite Instability , BRAF Mutant Metastatic Colon Cancer , Bibliography update , dMMR , BRAFV600E
Journal title :
Case Reports in Oncological Medicine
