Title of article
Down Presymptomatic View of Dementia Characteristics
Author/Authors
Joshaghanian, Mohammad Amin School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran Iran , Mohammadi, Sassan School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran Iran , Ghozloujeh, Zohreh Gholizadeh School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran Iran , Farahani, Mehrdad School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran Iran , Mojtabavi, Kurosh Cellular and Molecular Research Center & Department of Physiology - School of Medicine - Guilan University of Medical Sciences, Rasht, Iran
Pages
5
From page
1
To page
5
Abstract
Down syndrome (DS) is caused by complete or segmental chromosome 21 trisomy that results in neurodegeneration and progressive intellectual disability. Abnormal function in the prefrontal cortex, cerebellum, and hippocampus are the main reasons for cognitive deficits in DS that result in impaired cognitive function, delayed speech and language, learning and memory disability, and behavioral and emotional disorders. There is no specific treatment for DS, and our understanding of the mechanisms of the disorder is incomplete and causes to hamper the development of effective therapies regarding the development of neuropathology and memory loss in DS. Here, we review the literature on cognitive functioning, unique characteristics, environmental considerations, and recent findings on Alzheimer’s disease in DS.
Keywords
Down syndrome (DS) , Dementia , Alzheimer’s Disease , Cognitive deficits , Neurodegeneration
Journal title
International Clinical Neuroscience Journal
Serial Year
2020
Record number
2610708
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