Case ReportRadiation Recall Dermatitis in Patients Treated with Sorafenib

Radiation recall dermatitis (RRD) is a phenomenon that occurs in previously irradiated areas shortly after ad-ministration of a chemotherapeutic agent. As the use of sorafenib expands, the incidence of radiation recall dermatitis induced bysorafenib will likely increase. Here, we report on a patient who developed RRD and describe his clinical characteristics along witha review of the literature.Case Presentation. Our patient was treated with palliative radiation therapy (RT) to a painful metastatichepatocellular carcinoma lesion in the right forearm. He completed his radiation course with grade 1 dermatitis, which hadresolved by the time he was started on sorafenib 400 mg twice daily 7 days afterwards. On the 21st day after RT, he presented withdesquamation and erythema in the previously irradiated area of the right forearm, consistent with RRD. +e sorafenib wasdiscontinued and his symptoms subsequently resolved with conservative topical management.Conclusions. Although thepathophysiologic mechanism of sorafenib-related radiation recall dermatitis remains to be investigated, practitioners should beaware of its presence and management in order to improve clinical outcomes.