Author/Authors :
Wang, Rongyang Faculty of Mechanical Engineering and Automation - Zhejiang Sci-Tech University - Hangzhou, China , Wei, Yikun Faculty of Mechanical Engineering and Automation - Zhejiang Sci-Tech University - Hangzhou, China , Wu, Chuanyu Faculty of Mechanical Engineering and Automation - Zhejiang Sci-Tech University - Hangzhou, China , Sun, Liang Faculty of Mechanical Engineering and Automation - Zhejiang Sci-Tech University - Hangzhou, China , Zheng, Wenguang Faculty of Mechanical Engineering and Automation - Zhejiang Sci-Tech University - Hangzhou, China
Abstract :
The immersed boundary-lattice Boltzmann method (IB-LBM) was used to examine the motion and deformation of three elastic
red blood cells (RBCs) during Poiseuille fow through constricted microchannels. The objective was to determine the efects of the
degree of constriction and the Reynolds (Re) number of the fow on the physical characteristics of the RBCs. It was found that,
with decreasing constriction ratio, the RBCs experienced greater forced deformation as they squeezed through the constriction
area compared to at other parts of the microchannel. It was also observed that a longer time was required for the RBCs to squeeze
through a narrower constriction. The RBCs subsequently regained a stable shape and gradually migrated toward the centerline of
the fow beyond the constriction area. However, a sick RBC was observed to be incapable of passing through a constricted vessel
with a constriction ratio ≤1/3 for Re numbers below 0.40.
