Title of article
High Prevalence of Multidrug Resistant Bacteria in Cirrhotic Patients with Spontaneous Bacterial Peritonitis: Is It Time to Change the Standard Antimicrobial Approach?
Author/Authors
Conto Oliveira, Jerônimo De Post-Graduate Program in Gastroenterology and Hepatology - Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil , Carrera, Enrique World Gastroenterology Organization Porto Alegre Training Center, Porto Alegre, Brazil , Petry, Roberta C Post-Graduate Program in Gastroenterology and Hepatology - Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil , Deutschendorf, Caroline Infectious Disease Control Commission - Hospital de Cl´ınicas de Porto Alegre - Porto Alegre, Brazil , Mantovani, Augusto Division of Gastroenterology and Hepatology - Hospital de Clınicas de Porto Alegre - Porto Alegre, Brazil , Alrutz Barcelos, Samantha Thifani Post-Graduate Program in Gastroenterology and Hepatology - Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil , Cassales, Santiago Post-Graduate Program in Gastroenterology and Hepatology - Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil , Comunello Schacher, Fernando Post-Graduate Program in Gastroenterology and Hepatology - Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil , Barros Lopes, Antônio Division of Gastroenterology and Hepatology - Hospital de Clınicas de Porto Alegre - Porto Alegre, Brazil , Alvares-da-Silva, Mario R. Post-Graduate Program in Gastroenterology and Hepatology - Universidade Federal do Rio Grande do Sul - Porto Alegre, Brazil
Pages
6
From page
1
To page
6
Abstract
Introduction
Spontaneous bacterial peritonitis (SBP) has a deleterious clinical impact in end-stage liver disease, and multidrug resistance has increased, raising concern about effectiveness of traditional antibiotic regimens.
Patients and Methods
Single-center retrospective study of ascitic fluid infections in cirrhotic patients.
Results
We analyzed medical records related to 2129 culture-positive ascitic fluid and found 183 samples from cirrhotic patients. There were 113 monobacterial SBP cases from 97 cirrhotic patients; 57% of patients were male; hepatitis C and alcohol were the main etiologies for cirrhosis. Multidrug resistant bacteria were isolated in 46.9% of SBP samples, and third-generation cephalosporin and quinolone resistant reached 38.9% and 25.7% of SBP cases.
Conclusion
SBP due to multidrug resistant bacteria is a growing problem, and one should consider reported resistance profiles for the decision-making process of empirical first-line treatment prescription.
Keywords
High Prevalence , Multidrug Resistant Bacteria , Cirrhotic Patients , Spontaneous Bacterial Peritonitis
Journal title
Canadian Journal of Gastroenterology and Hepatology
Serial Year
2019
Record number
2611506
Link To Document