Author/Authors :
Kawakami, Keiki Department of Hematology and Oncology - Suzuka General Hospital - Yamanohana - Suzuka - Mie Prefecture , Japan , Harada, Shinichi Department of Hematology and Oncology - Suzuka General Hospital - Yamanohana - Suzuka - Mie Prefecture , Japan , Nagaharu, Keiki Department of Hematology and Oncology - Suzuka General Hospital - Yamanohana - Suzuka - Mie Prefecture , Japan , Baba, Youichirou Department of Pathology - Suzuka General Hospital - Yamanohana - Suzuka - Mie Prefecture , Japan , Murata, Tetsuya Department of Pathology - Suzuka General Hospital - Yamanohana - Suzuka - Mie Prefecture , Japan , Mizuno, Toshiro Department of Hematology and Oncology - Mie University Hospital - Edobashi - Tsu - Mie Prefecture , Japan
Abstract :
Tumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventuallyinduces metabolic abnormalities. TLS is observed mainly among tumors with rapid cell proliferation or high sensitivity toantineoplastic treatment. In rare cases, TLS occurs without any cytotoxic treatment. Previous reports have shown that alternativestress including proceeding infection or an operation might play a role in TLS. However, exact mechanism of spontaneousTLS remains unknown. Here, we describe a case of a 59-year-old woman who presented with dedifferentiated endometrialadenocarcinoma and developed TLS without any cytotoxic chemotherapy. Although spontaneous TLS in solid malignancies areextremely rare, clinicians should consider the possibilities of TLS especially in aggressive solid tumors
Keywords :
Spontaneous Tumor Lysis Syndrome , Patient , Dedifferentiated Endometrial Adenocarcinoma , Tumor lysis syndrome (TLS)
