Author/Authors :
Takei, Yoshiyuki Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Yamada, Reiko Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Inoue, Hiroyuki Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Sakuno, Takashi Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Harada, Tetsuro Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Yoshizawa, Naohiko Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Miura, Hiroshi Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Takeuchi, Toshihumi Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Nakamura, Misaki Department of Gastroenterology and Hepatology - Mie University Graduate School of Medicine - Tsu, Japan , Tanaka, Kyosuke Department of Endoscopy - Mie University School of Medicine - Tsu, Japan , Katsurahara, Masaki Department of Endoscopy - Mie University School of Medicine - Tsu, Japan , Hamada, Yasuhiko Department of Endoscopy - Mie University School of Medicine - Tsu, Japan , Horiki, Noriyuki Department of Endoscopy - Mie University School of Medicine - Tsu, Japan
Abstract :
A 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever. She was diagnosed withmetastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection. Her serum concentration of granulocytecolony-stimulating factor was highly elevated. Forty-five days after initiating chemotherapy, she was readmitted because of aneuropsychiatric disturbance and hypercalcemia. Her serum concentration of parathyroid hormone-related protein (PTH-rP) waselevated. A pretreatment biopsy specimen showed strong cytoplasmic immunoreactivity to anti-PTH-rP antibody, suggesting thatoverproduction of PTH-rP accounted for the hypercalcemia. Although the patient regained consciousness after treatment, she diedof progressive disease 60 days after chemotherapy.
Keywords :
Pancreatic Adenocarcinoma Producing , Parathyroid , Hormone-Related Protein , PTH-rP
