Author/Authors :
Kyriakopoulos, Christos Department of Pulmonary Medicine - Medical School - University of Ioannina - Ioannina, Greece , Zarkavelis, George Society for Study of the Clonal Heterogeneity of Neoplasia - Ioannina, Greece , Pentheroudakis, George Society for Study of the Clonal Heterogeneity of Neoplasia - Ioannina, Greece , Boussios, Stergios Society for Study of the Clonal Heterogeneity of Neoplasia - Ioannina, Greece , Andrianopoulou, Artemis Department of Radiology - Medical School - University of Ioannina - Ioannina, Greece , Papoudou-Bai, Alexandra Department of Pathology - Medical School - University of Ioannina - Ioannina, Greece , Stefanou, Dimitrios Department of Pathology - Medical School - University of Ioannina - Ioannina, Greece
Abstract :
Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are extremely rare.Published data on primary pulmonary malignant melanomas are limited. Up to now 40 relevant cases have been reported in theEnglish literature. Herein, we report a case of a 56-year-old female patient who presented with intracranial metastases due toprimary pulmonary melanoma. She underwent bronchoscopy and died 5 months after the initial diagnosis despite the administeredbiochemotherapy and subsequent immunotherapy. To establish the diagnosis of primary pulmonary malignant melanoma, anyextrapulmonary origin was excluded by detailed examination and radiographic imaging. Moreover, an extensive review of theliterature regarding this rare entity has been performed.
