Author/Authors :
Arvanitis, Dimitrios Leonidas Department of Anatomy - Faculty of Medicine - School of Health Sciences - University of Thessaly - Larissa, Greece , Zibis, Aristeidis Hristos Department of Anatomy - Faculty of Medicine - School of Health Sciences - University of Thessaly - Larissa, Greece , Fyllos, Apostolos Haralampos Department of Anatomy - Faculty of Medicine - School of Health Sciences - University of Thessaly - Larissa, Greece , Havaki, Sophia Department of Histology and Embryology - National and Kapodistrian University of Athens - Medical School - Athens, Greece , Sotiriou, Sotirios Department of Embryology - Faculty of Medicine - School of Health Sciences - University of Thessaly - Larissa, Greece , Kotakidis, Georgios Department of Urology - General Hospital of Florina - Florina, Greece
Abstract :
We report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as areddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrineadenocarcinoma with pagetoid phenomenon. The tumor recurred after four months and then excision biopsy showed tumor withpagetoid phenomenon which reached all the surgical margins. Three months later an ulcerated nodule in the scrotum and greatlyenlarged ipsilateral inguinal lymph nodes were noticed. The final pathological examination showed multiple separated malignantfoci, some with overlying pagetoid phenomenon and inguinal lymph node metastases. Immunohistochemistry showed positivityfor Gross Cystic Disease Fluid Protein-15 (GCDFP-15), androgen receptors, and score 3+ for the Human Epidermal growth factorReceptor-2 (HER2). The aggressive behavior of the present tumor goes along with previous reports showing that HER2 high scorecases exhibit a worse prognosis.
Keywords :
Scrotal Apocrine Adenocarcinoma , Pagetoid Phenomenon , Inguinal Lymph Node Metastases , GCDFP-15 , HER2
