Poor Outcomes in Hepatic Amyloidosis: A Report of 2 Cases

Hepatic amyloidosis is a rare disease entity that results from insoluble amyloid protein deposition in the liver. The disease oftenpresents with vague, nonspecific clinical features. Currently, there is little literature describing treatment outcomes for biopsy-proven hepatic amyloidosis and current treatment guidelines recommend that patients enroll in a clinical trial due to insufficientevidence to suggest an optimal treatment regimen. Here, we present two cases of hepatic amyloidosis at an academic medical centerand describe their presentation, treatment, and outcomes. These cases highlight the poor outcomes and difficult management ofhepatic amyloidosis. Further understanding and investigation of this rare disease are warranted